One significant improvement in Rosetta accessibility was the development of the PyRosetta package ( Chaudhury et al., 2010), which provides Python bindings to several of the main Rosetta protocols and permits the user to design their own customized protocols using these bindings in Python scripts. Unfortunately, the main Rosetta software package has a command-line interface, intended for use on Unix operating systems, which limits its usability mainly to researchers with extensive C++ and Unix operating system experience. One significant software package is the Rosetta protein modeling suite ( Leaver-Fay, 2011), which provides access to a wide array of structural modeling tools which have been successfully used for protein engineering, including protein design ( Kuhlman, 2003), structure prediction ( Raman et al., 2009), loop modeling ( Mandell et al., 2009) and protein docking ( Chaudhury, 2008), among other tools. InteractiveROSETTA is also capable of interacting with remote Rosetta servers, facilitating sophisticated protocols that are not accessible in PyRosetta or which require greater computational resources.Īvailability and implementation: InteractiveROSETTA is freely available at and relies upon a separate download of PyRosetta which is available at after obtaining a license (free for academic use).Ĭomputational molecular modeling has exhibited significant advances over the past several years, leading to its more widespread use in academic and commercial research for novel structural engineering applications. Here, we present InteractiveROSETTA, a graphical interface for the PyRosetta framework that presents easy-to-use controls for several of the most widely used Rosetta protocols alongside a sophisticated selection system utilizing PyMOL as a visualizer. Some graphical interfaces for Rosetta exist, but typically are not as sophisticated as commercial software. ![]() Unfortunately, Rosetta is largely a command-line-driven software package which restricts its use among non-computational researchers. ![]() Rosetta is one such protein modeling suite that has already demonstrated wide applicability to a number of diverse research projects. Summary: Modern biotechnical research is becoming increasingly reliant on computational structural modeling programs to develop novel solutions to scientific questions.
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